Abzyme has the ability to rapidly clone antibodies from B cells of immunized rabbits into our yeast display system and to isolate clones that have the desired biological activity using our established screening and selection approach.
Partners typically provide PBMCs or whole blood from immunized rabbits. Within approximately 8 – 12 weeks, 200 µg of sequence-verified rabbit recombinant antibodies are available for biological assessment. We also offer a complete rabbit monoclonal antibody development package starting from rabbit immunization to final antibody production.
Once antibodies are identified that have the desired biological activity, we can quickly improve the lead candidates using our various optimization and humanization techniques. Optimization may include engineering for higher affinity, manufacturability and target cross-reactivity.
Our key advantages are:
• Ability to clone and produce rabbit and rabbit/human chimeric IgGs from rabbit sources in 8 – 12 weeks.
• Rapid improvement of lead candidates using a variety of maturation/optimization techniques.